Classics In Total Synthesis Ii Pdf 16
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How to Learn from the Masters of Organic Synthesis: A Review of Classics in Total Synthesis II
If you are interested in learning the art and science of organic synthesis, you may want to read Classics in Total Synthesis II: More Targets, Strategies, Methods by K. C. Nicolaou and Scott A. Snyder. This book is the sequel to the acclaimed Classics in Total Synthesis, which was published in 1996 and covered some of the most impressive achievements in natural product total synthesis until then.
Classics in Total Synthesis II presents 22 new and modern total syntheses of complex natural products, such as vancomycin, epothilone A, quinine, vinblastine, and diazonamide A. Each chapter describes the synthetic strategy, the key reactions, and the challenges and solutions encountered by the synthetic chemists. The book also includes a CD-ROM with teaching material and animations of some of the reactions.
The book is not only a collection of facts and procedures, but also a source of inspiration and education for anyone who wants to master organic synthesis. The authors explain the logic and creativity behind each synthetic plan, and highlight the domino reactions, cascade sequences, biomimetic strategies, and asymmetric catalysis that are frequently used in modern synthesis. They also discuss the latest synthetic technologies, such as olefin metathesis, C-H activation, and organocatalysis.
Classics in Total Synthesis II is a must-read for graduate students, educators, and researchers in the fields of synthetic and medicinal chemistry. It will help you to appreciate the beauty and elegance of organic synthesis, and to learn from the masters of this fascinating discipline.
Some Examples of Total Syntheses from the Book
To give you a taste of what you can find in Classics in Total Synthesis II, here are some examples of the total syntheses that are discussed in the book.
Vancomycin: This is a glycopeptide antibiotic that is used to treat serious infections caused by resistant bacteria. The total synthesis of vancomycin was achieved by Dale L. Boger and coworkers in 1999, after more than a decade of research. The synthesis involved 123 steps and required the assembly of seven amino acid units, four glycosyl units, and a trisulfide bridge. The synthesis also featured a remarkable [4+2] cycloaddition reaction to construct the biaryl ether bond, which is essential for the biological activity of vancomycin.
Epothilone A: This is a macrocyclic lactone that has potent anticancer activity by stabilizing microtubules. The total synthesis of epothilone A was accomplished by Samuel J. Danishefsky and coworkers in 1996, using a convergent strategy that involved the coupling of two fragments: a 16-membered macrolactone and a triene side chain. The synthesis also showcased a remarkable ring-closing metathesis reaction to form the macrolactone ring, which was catalyzed by a ruthenium complex.
Quinine: This is an alkaloid that has been used for centuries to treat malaria. The total synthesis of quinine was achieved by Gilbert Stork and coworkers in 2001, using a biomimetic approach that mimicked the biosynthesis of quinine from tryptophan. The synthesis involved 18 steps and featured a remarkable intramolecular Diels-Alder reaction to form the quinoline ring, followed by an oxidative rearrangement to form the quinuclidine ring.
These are just some of the amazing total syntheses that you can learn from Classics in Total Synthesis II. If you want to discover more, you can order the book from Wiley or download the PDF from various online sources. aa16f39245